Issued in 1974, 45 CFR 46 raised to regulatory status: Top 1000 Questions Issued in 1974, 45 CFR 46 raised to regulatory status:Answer: US Public Health Service Policy (45 CFR 46 raised to regulatory status the US Public Health Service policy of 1966 "Clinical research and investigation involving human beings".) Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+